HS Disease

Causes

• The underlying cause of hidradenitis suppurativa remains uncertain, but current evidence suggests an immune-mediated mechanism.

   

• Associated factors: 
  • Genetics
    • Approximately ⅓ of patients report a family history of HS. Researchers have evaluated inheritance patterns in families affected by HS and performed DNA analysis to determine whether genetic changes correlate with the development of HS. Based upon the “family trees” (pedigrees) and genetic analysis, it appears that HS in some families is inherited in an autosomal dominant manner. This means the gene only needs to be inherited from one parent. Genetic mutations in combination with other factors may result in HS.
  • Mechanical Stress (pressure, friction, shear)
  • Obesity
  • Smoking 
  • Bacteria 

  • Drugs 

     

References:

Ingram J. (2025) Hidradenitis suppurativa: Pathogenesis, clinical features, and diagnosis. UpToDate. Retrieved October 21, 2025.